Cart
sales@molnova.com
Nrf2 activator-4
CAS No. 2383016-68-8
Nrf2 activator-4( —— )
Catalog No. M35687 CAS No. 2383016-68-8
Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 105 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNrf2 activator-4
-
NoteResearch use only, not for human use.
-
Brief DescriptionNrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
-
DescriptionNrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorReactive Oxygen Species | Nrf2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2383016-68-8
-
Formula Weight468.9
-
Molecular FormulaC23H24ClF3N2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (213.27 mM; Ultrasonic )
-
SMILESCl.CN1CCN(CC1)C(=O)COc1ccc(cc1)C(=O)\C=C\c1ccccc1C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777. ?
molnova catalog
related products
-
AZ13705339
AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.
-
Boc-Gln-Ala-Arg-AMC ...
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorescent compound used as a substrate for trypsin and for assessing the protein hydrolysis activity of TMPRSS2.
-
DSR-6434
DSR-6434 has a strong antitumor effect. DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively.
